Most sedating antidepressants
Of the 21 antidepressants studied, all of them worked better than a placebo."In the short-term, for acute depression, antidepressants seem to work modestly," said study author Dr. He's a professor of disease prevention at Stanford University in California.Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness; possibly drowsiness, dry mouth, constipation.It’s the worst one for weight gain, and among the worst for withdrawal symptoms (unless properly managed).Side effects: Jitteriness, insomnia, headaches, dry mouth, nausea (and, rarely, risk of seizure).Whom it may be suitable for: Not an ideal first-line treatment: Start-up can be difficult to tolerate, and serotonin is often needed to effect mood change.Some antidepressants, though, are more effective and better tolerated than others, the findings showed.
Pros: This norepinephrine dopamine reuptake inhibitor (NDRI) is often added on to other antidepressant treatments that lose effectiveness over time or cause sexual dysfunction.Pros: This SSRI has fewer overall side effects than some antidepressants, but the serotonin-related side effects can be powerful.Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness, dry mouth, drowsiness.Whom it may be suitable for: Those whose depression causes fatigue; also ideal for anxiety symptoms and anxiety disorders; not ideal where weight gain is a health concern.Pros: Some find this SSRI has the fewest side effects.
Other common side effects: headache, dry mouth, constipation, sweating, dizziness, sexual dysfunction.